pentobarbital will lower the extent or effect of etravirine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will lower the level or outcome of lonafarnib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib can be a delicate CYP3A4 substrate. Coadministration with